Senescence-Associated Secretory Phenotype [sekreční fenotyp asociovaný se senescencí]

topical
2
Terms

SASP
sekreční fenotyp spojený se senescencí

 

Senescent Cell SASP

Persistent link   https://www.medvik.cz/link/D000089262
Definition

A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.

DUI
D000089262 MeSH Browser
CUI
M000630264
History note
2022; use CELLULAR SENESCENCE 2018-2021
Public note
2022; see CELLULAR SENESCENCE 2018-2021

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G04 Cell Physiological Phenomena 515
G04.043 Cellular Senescence 230
G04.043.260 Erythrocyte Aging 21
G04.043.445 Senescence-Associated Secretory Phenotype 2
G04.043.538 T-Cell Senescence
G04.043.630 Telomere Shortening 35
G07 Physiological Phenomena 176
G07.345 Growth and Development 247
G07.345.124 Aging 4 015
G07.345.124.130 Cellular Senescence 230
G07.345.124.130.260 Erythrocyte Aging 21
G07.345.124.130.445 Senescence-Associated Secretory Phenotype 2
G07.345.124.130.630 Telomere Shortening 35

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