Shelterin Complex [shelterinový komplex]

topical
2
Terms

CST komplex
CTC1-STN1-TEN1 komplex
komplex CST
komplex CTC1-STN1-TEN1
komplex POT1-TPP1
shelterin komplex
telomerový komplex Stn1-Ten1
telosom
telozom

 

CST Complex
Ctc1-Stn1-Ten1 Complex
POT1-TPP1 Shelterin Complex
Telomere Cap Complex
Telomere POT1-TPP1 Complex
Telomeric Capping Complex
Telomeric Stn1-Ten1 Capping Complex
Telosome

Persistent link   https://www.medvik.cz/link/D000089804
Definition

A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

DUI
D000089804 MeSH Browser
CUI
M000744989
Previous indexing
Telomere-Binding Proteins (2005-2021)
History note
2022
Public note
2022

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

A Anatomy
A11 Cells 976
A11.284 Cellular Structures 40
A11.284.430 Intracellular Space 84
A11.284.430.106 Cell Nucleus 811
A11.284.430.106.279 Cell Nucleus Structures 30
A11.284.430.106.279.345 Intranuclear Space 3
A11.284.430.106.279.345.190 Chromosomes 473
A11.284.430.106.279.345.190.160 Chromosome Structures 8
A11.284.430.106.279.345.190.160.845 Telomere 281
A11.284.430.106.279.345.190.160.845.500 Shelterin Complex 2
A11.284.430.106.279.345.190.160.845.500.500 Telomeric Repeat Binding Protein 1 4
A11.284.430.106.279.345.190.160.845.500.750 Telomeric Repeat Binding Protein 2 6

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.049 Amyloid 166
D05.500.099 Apoptosomes 2
D05.500.117 Axin Signaling Complex 1
D05.500.135 Calcifying Nanoparticles 1
D05.500.139 COP9 Signalosome Complex
D05.500.142 Dynactin Complex 1
D05.500.149 Dystrophin-Associated Protein Complex 1
D05.500.199 Endosomal Sorting Complexes Required for Transport 8
D05.500.224 Inflammasomes 27
D05.500.299 Lactose Synthase
D05.500.337 Mechanistic Target of Rapamycin Complex 1 18
D05.500.356 Mechanistic Target of Rapamycin Complex 2 3
D05.500.374 Mediator Complex 5
D05.500.437 Mitochondrial Permeability Transition Pore 8
D05.500.469 Mitochondrial Precursor Protein Import Complex Proteins
D05.500.500 Molecular Motor Proteins 11
D05.500.562 Multienzyme Complexes 40
D05.500.672 NF-kappa B 220
D05.500.781 Polycomb-Group Proteins 7
D05.500.890 Protein Translocation Systems
D05.500.918 Shelterin Complex 2
D05.500.945 Troponin 266
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.260 DNA-Binding Proteins 561
D12.776.260.735 Telomere-Binding Proteins 24
D12.776.260.735.500 Heterogeneous-Nuclear Ribonucleoprotein Group A-B 2
D12.776.260.735.625 Shelterin Complex 2
D12.776.260.735.750 Telomeric Repeat Binding Protein 1 4
D12.776.260.735.875 Telomeric Repeat Binding Protein 2 6
D12.776.660 Nuclear Proteins 455
D12.776.660.235 Chromosomal Proteins, Non-Histone 93
D12.776.660.235.700 Telomere-Binding Proteins 24
D12.776.660.235.700.500 Heterogeneous-Nuclear Ribonucleoprotein Group A-B 2
D12.776.660.235.700.625 Shelterin Complex 2
D12.776.660.235.700.750 Telomeric Repeat Binding Protein 1 4
D12.776.660.235.700.875 Telomeric Repeat Binding Protein 2 6
D12.776.664 Nucleoproteins 91
D12.776.664.224 Chromatin 337
D12.776.664.235 Chromosomal Proteins, Non-Histone 93
D12.776.664.275 Deoxyribonucleoproteins 13
D12.776.664.469 Histones 371
D12.776.664.750 Protamines 43
D12.776.664.962 RNA-Binding Proteins 158
D12.776.664.981 Shelterin Complex 2
D12.776.664.981.500 Telomeric Repeat Binding Protein 1 4
D12.776.664.981.750 Telomeric Repeat Binding Protein 2 6

G Phenomena and Processes
G05 Genetic Phenomena 135
G05.360 Genetic Structures 25
G05.360.160 Chromosome Structures 8
G05.360.160.845 Telomere 281
G05.360.160.845.500 Shelterin Complex 2
G05.360.160.845.500.500 Telomeric Repeat Binding Protein 2 6

ACD protein, human Chemical MeSH Browser

POT1 protein, human Chemical MeSH Browser

POT1 protein, mouse Chemical MeSH Browser

Pot1 protein, Arabidopsis Chemical MeSH Browser

RAP1 protein, Candida albicans Chemical MeSH Browser

RAP1 protein, Drosophila Chemical MeSH Browser

RAP1 protein, S cerevisiae Chemical MeSH Browser

Rap1 protein, S pombe Chemical MeSH Browser

TERF1 protein, human Chemical MeSH Browser

TERF2IP protein, human Chemical MeSH Browser

TERF2IP protein, mouse Chemical MeSH Browser

TPP1 protein, zebrafish Chemical MeSH Browser

pot1 protein, S pombe Chemical MeSH Browser

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