Fibroblast Activation Protein Alpha [fibroblastový aktivační protein alfa]

topical
Terms

FAP
FAP alfa
sepráza

 

FAPalpha
Fibroblast Activation Protein-alpha
Seprase
Surface Expressed Protease

Persistent link   https://www.medvik.cz/link/D000099167
Definition

A large, gelatin-degrading membrane SERINE ENDOPEPTIDASE complex expressed by stromal FIBROBLASTS of epithelial cancers; it is a biomarker for MELANOMA cell invasiveness.

DUI
D000099167 MeSH Browser
CUI
M000768845
History note
2026 (1994)
Public note
2026 (1994); FIBROBLAST ACTIVATION PROTEIN ALPHA was indexed under MEMBRANE PROTEINS and ENDOPEPTIDASES 1994-2025

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 557
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 563
D08.811.277.656.300 Endopeptidases 214
D08.811.277.656.300.032 Amyloid Precursor Protein Secretases 37
D08.811.277.656.300.048 Aspartic Acid Endopeptidases 47
D08.811.277.656.300.065 ATP-Dependent Endopeptidases
D08.811.277.656.300.099 Brinolase
D08.811.277.656.300.174 Coagulase 70
D08.811.277.656.300.200 Cysteine Endopeptidases 44
D08.811.277.656.300.340 Fibroblast Activation Protein Alpha
D08.811.277.656.300.480 Metalloendopeptidases 40
D08.811.277.656.300.760 Serine Endopeptidases 138
D08.811.277.656.300.775 Streptokinase 209
D08.811.277.656.300.887 Ubiquitin-Specific Proteases 10
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 596
D12.776.543 Membrane Proteins 860
D12.776.543.019 5-Lipoxygenase-Activating Proteins 1
D12.776.543.024 Adducins
D12.776.543.029 Amphiregulin 3
D12.776.543.039 Amyloid beta-Protein Precursor 63
D12.776.543.080 Ankyrins 10
D12.776.543.090 Arrestins 6
D12.776.543.095 B7 Antigens 3
D12.776.543.100 Bacterial Outer Membrane Proteins 95
D12.776.543.116 Bcl-2-Like Protein 11 5
D12.776.543.131 Cadherin Related Proteins 1
D12.776.543.162 Calnexin 4
D12.776.543.178 Carbonic Anhydrase IX 21
D12.776.543.193 Chemokine CX3CL1 4
D12.776.543.200 Cornified Envelope Proline-Rich Proteins 2
D12.776.543.213 Discs Large Homolog 1 Protein
D12.776.543.219 Disks Large Homolog 4 Protein 1
D12.776.543.225 Dysferlin
D12.776.543.250 Dystrophin 46
D12.776.543.268 Dystrophin-Associated Proteins
D12.776.543.277 Electron Transport Chain Complex Proteins 31
D12.776.543.287 Ephrins 1
D12.776.543.297 Fibroblast Activation Protein Alpha
D12.776.543.302 Frizzled-Related Proteins
D12.776.543.303 Phospholamban
D12.776.543.306 gp100 Melanoma Antigen 1
D12.776.543.325 Heterotrimeric GTP-Binding Proteins 14
D12.776.543.475 LDL-Receptor Related Protein-Associated Protein
D12.776.543.484 Lipid-Linked Proteins 1
D12.776.543.488 MARVEL Domain-Containing Proteins 1
D12.776.543.493 Matrix Metalloproteinases, Membrane-Associated 1
D12.776.543.512 Membrane Fusion Proteins
D12.776.543.550 Membrane Glycoproteins 203
D12.776.543.585 Membrane Transport Proteins 209
D12.776.543.602 Mitochondrial Trifunctional Protein 2
D12.776.543.620 Myelin Proteins 32
D12.776.543.637 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.543.653 NADPH Oxidases 45
D12.776.543.685 Neurofibromin 2 3
D12.776.543.689 Peroxisomal Biogenesis Factor 2
D12.776.543.693 Phospholipid Transfer Proteins 6
D12.776.543.695 Pore Forming Cytotoxic Proteins 8
D12.776.543.696 Presenilins 6
D12.776.543.697 Protoporphyrinogen Oxidase 7
D12.776.543.701 Pulmonary Surfactant-Associated Protein B 4
D12.776.543.717 Pulmonary Surfactant-Associated Protein C 5
D12.776.543.725 Receptor Activity-Modifying Proteins 1
D12.776.543.733 Receptor-Like Protein Tyrosine Phosphatases
D12.776.543.750 Receptors, Cell Surface 513
D12.776.543.800 Serrate-Jagged Proteins 1
D12.776.543.850 Spectrin 20
D12.776.543.860 STING Protein
D12.776.543.875 Stromal Interaction Molecules 3
D12.776.543.900 Tetraspanins 13
D12.776.543.930 Thylakoid Membrane Proteins 1
D12.776.543.935 Thyroid Hormone-Binding Proteins
D12.776.543.940 Tight Junction Proteins 6
D12.776.543.985 Utrophin 1
D12.776.543.990 Vesicular Transport Proteins 46

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