A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

DUI

D000584 MeSH Browser

CUI

M0000906

CAS

Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-

Previous indexing

Diuretics (1966-1971); Pyrazines (1966-1971)

History note

86(72); was see under PYRAZINES 1975-85, was Prov 1972-74

Public note

86; was see under PYRAZINES 1975-85