5-Aminolevulinate Synthetase [5-aminolevulátsynthetasa]
- Terms
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5-ALA syntetáza
5-aminolevulát syntáza
5-aminolevulát syntetáza
5-aminolevulát synthetasa
5-aminolevulátsyntetáza
syntetáza kyseliny aminolevulové
synthetasa kyseliny aminolevulové
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5-Aminolevulinate Synthase
Aminolevulinic Acid Synthetase
delta-Aminolevulinate Synthase
delta-Aminolevulinic Acid Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
- DUI
- D000624 MeSH Browser
- CUI
- M0000954
- CAS
- Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
- Previous indexing
- Acyltransferases (1966-1971)
- History note
- 98(72)
- Public note
- 98; see AMINOLEVULINIC ACID SYNTHETASE 1972-97
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 2
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 2
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 1
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
ALAS1 protein, human Chemical MeSH Browser
ALAS2 protein, human Chemical MeSH Browser
ALAS2 protein, mouse Chemical MeSH Browser
aminolevulinate synthase, S cerevisiae Chemical MeSH Browser