An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.

DUI

D007862 MeSH Browser

CUI

M0012276

CAS

Phosphatidylcholine:sterol O-acyltransferase

Previous indexing

Acyltransferases (1966-1974); Cholesterol (1966-1974); Phosphatidylcholines (1966-1974)

History note

98(75)

Public note

98; see LECITHIN ACYLTRANSFERASE 1978-97; see ACYLTRANSFERASES 1975-77