Cardiac Glycosides [srdeční glykosidy]
- Terms
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Cardiac Glycoside
Cardiotonic Steroid
Cardiotonic Steroids
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
- DUI
- D002301 MeSH Browser
- CUI
- M0003451
Allowable subheadings
- AD
- administration & dosage 18
- AE
- adverse effects 13
- AG
- agonists
- AN
- analysis 6
- AI
- antagonists & inhibitors
- BI
- biosynthesis 5
- BL
- blood 2
- CF
- cerebrospinal fluid
- CS
- chemical synthesis 1
- CH
- chemistry 6
- CL
- classification 4
- EC
- economics
- GE
- genetics
- HI
- history 1
- IM
- immunology
- IP
- isolation & purification 6
- ME
- metabolism 7
- PK
- pharmacokinetics 5
- PD
- pharmacology 33
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 47
- TO
- toxicity 12
- UR
- urine
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