Toxin produkovaný bakterií Vibrio cholerae; gen je uložen na chromozomu bakterie. Choleragenoid je toxoid cholery. (cit. Velký lékařský slovník online, 2015 http://lekarske.slovniky.cz/ ). Cholerový toxin je termolabilní enterotoxinový oligomerní protein, který se skládá ze dvou subjednotek A bez imunogenních schopností a pěti subjednotek B - označované jako choleragenoid - s imunogenními vlastnostmi.

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Anotace

/antag permitted but consider also ANTITOXINS

DUI

D002772 MeSH Prohlížeč

CUI

M0004245

Předchozí užití

Bacterial Toxins (1977); Bacterial Proteins (1966-1977); Enterotoxins (1966-1977); Toxins (1966-1967)

Historická pozn.

78

Veřejná pozn.

78