Cholera Toxin [cholerový toxin]
- Terms
-
cholera - toxin
choleragen
choleragenoid
podjednotka A cholerového toxinu
podjednotka B cholerového toxinu
procholeragenoid
-
Cholera Enterotoxin CT
Cholera Exotoxin
Cholera Toxin A
Cholera Toxin A Subunit
Cholera Toxin B
Cholera Toxin B Subunit
Cholera Toxin Protomer A
Cholera Toxin Protomer B
Cholera Toxin Subunit A
Cholera Toxin Subunit B
Choleragen
Choleragenoid
Procholeragenoid
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
- Annotation
- /antag permitted but consider also ANTITOXINS
- DUI
- D002772 MeSH Browser
- CUI
- M0004245
- Previous indexing
- Bacterial Toxins (1977); Bacterial Proteins (1966-1977); Enterotoxins (1966-1977); Toxins (1966-1967)
- History note
- 78
- Public note
- 78
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis 1
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 4
- CL
- classification
- EC
- economics
- GE
- genetics 3
- HI
- history 1
- IM
- immunology 3
- IP
- isolation & purification
- ME
- metabolism 2
- PK
- pharmacokinetics 1
- PD
- pharmacology 2
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UR
- urine
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