An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

DUI

D002945 MeSH Browser

CUI

M0004505

CAS

Platinum, diamminedichloro-, (SP-4-2)-

Previous indexing

Amines (1966-1973); Ammonium Compounds (1966-1973); Chlorides (1966-1973); Platinum (1966-1973)

History note

84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83

Online note

use CISPLATIN to search PLATINUM DIAMMINODICHLORIDE 1974-80 & DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-83

Public note

84; was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83