An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Annotation

cocaine derivatives = COCAINE /analogs; CRACK COCAINE, COCAINE SMOKING and COCAINE-RELATED DISORDERS are available

deriváty kokainu = KOKAIN /analogy a deriváty; k dispozici jsou i deskriptory KOKAIN KRYSTALICKÝ a PORUCHY SPOJENÉ S UŽÍVÁNÍM KOKAINU

DUI

D003042 MeSH Browser

CUI

M0004670

CAS

8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-

History note

COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74

Online note

use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74

Public note

COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74