Complement C3 Nephritic Factor [komplement C3 nefritický faktor]
topical
3
- Terms
-
komplement 3 nefritický faktor
-
C 3 Nephritic Factor
C3 NeF
C3 NeF IgG Autoantibodies
C3 NeF IgG Autoantibody
C3 Nephritic Factor
C3NeF IgG Autoantibodies
C3NeF IgG Autoantibody
Complement 3 Nephritic Factor
Persistent link
https://www.medvik.cz/link/D003178
Definition
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
- DUI
- D003178 MeSH Browser
- CUI
- M0004930
- Previous indexing
- Blood Proteins (1966-1977); Complement 3 (1975-1977)
- History note
- 2006 (1978)
- Public note
- 2006; see COMPLEMENT 3 NEPHRITIC FACTOR 1991-2005, see COMPLEMENT INACTIVATORS 1978-1990
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
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- AN
- analysis 1
- AI
- antagonists & inhibitors 0
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- biosynthesis 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 0
- HI
- history 0
- IM
- immunology 1
- IP
- isolation & purification 0
- ME
- metabolism 1
- PK
- pharmacokinetics 0
- PD
- pharmacology 1
- PH
- physiology 0
- PO
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- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
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- UR
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...
Occurrences in Medvik records