Debrisoquin [debrisochin]
topical
2
- Terms
-
Debrisoquine
Tendor
Persistent link
https://www.medvik.cz/link/D003647
Definition
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
- DUI
- D003647 MeSH Browser
- CUI
- M0005709
- CAS
- 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
- Previous indexing
- Antihypertensive Agents (1966-1972); Isoquinolines (1969-1972)
- History note
- 91(73); was see under ISOQUINOLINES 1973-90
- Public note
- 91; was see under ISOQUINOLINES 1973-90
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs