An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

DUI

D003647 MeSH Prohlížeč

CUI

M0005709

CAS

2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-

Předchozí užití

Antihypertensive Agents (1966-1972); Isoquinolines (1969-1972)

Historická pozn.

91(73); was see under ISOQUINOLINES 1973-90

Veřejná pozn.

91; was see under ISOQUINOLINES 1973-90