Diphtheria Toxin [difterický toxin]
- Terms
-
toxin Corynebacterium diphtheriae
-
Corynebacterium Diphtheriae Toxin
Toxin, Corynebacterium Diphtheriae
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
- Annotation
- /antag permitted but consider also DIPHTHERIA ANTITOXIN
- podheslo /antagonisté a inhibitory je povolené, ale zvaž i deskriptor DIFTERICKÝ ANTITOXIN
- DUI
- D004167 MeSH Browser
- CUI
- M0006522
Allowable subheadings
- AD
- administration & dosage 2
- AE
- adverse effects 2
- AG
- agonists
- AN
- analysis 1
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 2
- PK
- pharmacokinetics
- PD
- pharmacology 1
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity 2
- UR
- urine
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