Disulfiram [disulfiram]
- Terms
-
1,1'-disulfandiylbis(N,N-diethylmethanthioamid)
Antabus
tetraethyldisulfandikarbothioamid
tetraethylthiuramdisulfid
-
Alcophobin
Antabus
Antabuse
Anticol
Bis(diethylthiocarbamoyl) Disulfide
Dicupral
Esperal
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Tetraethylthiuram Disulfide
Teturam
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
- DUI
- D004221 MeSH Browser
- CUI
- M0006600
- CAS
- Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
Allowable subheadings
- AD
- administration & dosage 13
- AE
- adverse effects 9
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis 2
- AI
- antagonists & inhibitors
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 4
- CL
- classification
- EC
- economics
- HI
- history 1
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 4
- PK
- pharmacokinetics 1
- PD
- pharmacology 21
- PO
- poisoning 1
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 38
- TO
- toxicity 3
- UR
- urine 2
disulfiram-copper Chemical MeSH Browser