This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.

Annotation

almost always NIM with no subheadings; check HUMAN; do not routinely add neoplasm term

DUI

D007624 MeSH Browser

CUI

M0011933

Previous indexing

Tissue Culture (1966-1971); Cell Line (1969-1984)

History note

85

Public note

85