Methylenetetrahydrofolate Dehydrogenase (NADP) [methylentetrahydrofolátdehydrogenasa (NADP)]
- Terms
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methylentetrahydrofolátdehydrogenasa (NADP+)
methylentetrahydrofolátdehydrogenáza (NADP)
metylentetrahydrofolátdehydrogenáza (NADP)
-
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
- Annotation
- do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
- DUI
- D008754 MeSH Browser
- CUI
- M0013632
- CAS
- 5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
- Previous indexing
- Oxidoreductases (1973-1974); Tetrahydrofolates (1973-1974)
- History note
- 2004(1975);
- Public note
- 2004; see METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1991-2003; see OXIDOREDUCTASES 1975-1990
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