An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.

Annotation

do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)

DUI

D008754 MeSH Browser

CUI

M0013632

CAS

5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase

Previous indexing

Oxidoreductases (1973-1974); Tetrahydrofolates (1973-1974)

History note

2004(1975);

Public note

2004; see METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1991-2003; see OXIDOREDUCTASES 1975-1990