Nitric Oxide [oxid dusnatý]
- Terms
-
NO
-
Endogenous Nitrate Vasodilator
Mononitrogen Monoxide
Nitric Oxide, Endothelium-Derived
Nitrogen Monoxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
- DUI
- D009569 MeSH Browser
- CUI
- M0014877
- CAS
- Nitrogen oxide (NO)
- History note
- 1965
- Public note
- 1965
Allowable subheadings
- AD
- administration & dosage 53
- AE
- adverse effects 50
- AG
- agonists 1
- AA
- analogs & derivatives 2
- AN
- analysis 115
- AI
- antagonists & inhibitors 61
- BI
- biosynthesis 118
- BL
- blood 27
- CF
- cerebrospinal fluid
- CS
- chemical synthesis 12
- CH
- chemistry 43
- CL
- classification 4
- DF
- deficiency 62
- EC
- economics
- GE
- genetics 5
- HI
- history 7
- IM
- immunology 14
- IP
- isolation & purification 7
- ME
- metabolism 359
- PK
- pharmacokinetics 12
- PD
- pharmacology 78
- PH
- physiology 184
- PO
- poisoning
- RE
- radiation effects 2
- ST
- standards 3
- SD
- supply & distribution
- TU
- therapeutic use 124
- TO
- toxicity 13
- UR
- urine 3
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