Pyruvate Dehydrogenase Complex [pyruvátdehydrogenasový komplex]

topical
12
Terms

pyruvátdehydrogenázový komplex

Persistent link   https://www.medvik.cz/link/D011768
Definition

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

DUI
D011768 MeSH Browser
CUI
M0018291
Previous indexing
Oxidoreductases (1966-1972); Pyruvate Oxidase (1966-1972); Pyruvates (1966-1972)
History note
74(73)
Public note
74

Combination

deficiency
Pyruvate Dehydrogenase Complex Deficiency Disease

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis 1
AI
antagonists & inhibitors 1
BI
biosynthesis
BL
blood 1
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects 1
EC
economics
GE
genetics
HI
history
IM
immunology 1
IP
isolation & purification
ME
metabolism 6
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.562 Multienzyme Complexes 40
D05.500.562.249 Electron Transport Complex I 44
D05.500.562.374 Electron Transport Complex IV 221
D05.500.562.405 Exosome Multienzyme Ribonuclease Complex 12
D05.500.562.444 Fatty Acid Synthase, Type II 1
D05.500.562.452 Glycine Decarboxylase Complex 1
D05.500.562.468 Ketoglutarate Dehydrogenase Complex 8
D05.500.562.484 Phosphoenolpyruvate Sugar Phosphotransferase System
D05.500.562.488 Photosynthetic Reaction Center Complex Proteins 14
D05.500.562.500 Proteasome Endopeptidase Complex 96
D05.500.562.625 Pyruvate Dehydrogenase Complex 12
D05.500.562.625.500 Dihydrolipoamide Dehydrogenase 17
D05.500.562.625.750 Dihydrolipoyllysine-Residue Acetyltransferase 1
D05.500.562.625.875 Pyruvate Dehydrogenase (Lipoamide) 1
D05.500.562.750 Succinate Cytochrome c Oxidoreductase 4
D05.500.562.875 Sucrase-Isomaltase Complex 1
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.600 Multienzyme Complexes 40
D08.811.600.075 Anthranilate Phosphoribosyltransferase 1
D08.811.600.085 Anthranilate Synthase 1
D08.811.600.250 Electron Transport Chain Complex Proteins 31
D08.811.600.283 Exosome Multienzyme Ribonuclease Complex 12
D08.811.600.354 Fatty Acid Synthase, Type II 1
D08.811.600.391 Glycine Decarboxylase Complex 1
D08.811.600.465 Ketoglutarate Dehydrogenase Complex 8
D08.811.600.620 Mi-2 Nucleosome Remodeling and Deacetylase Complex 2
D08.811.600.700 Phosphoenolpyruvate Sugar Phosphotransferase System
D08.811.600.710 Photosynthetic Reaction Center Complex Proteins 14
D08.811.600.715 Polyketide Synthases 6
D08.811.600.720 Prostaglandin-Endoperoxide Synthases 40
D08.811.600.730 Proteasome Endopeptidase Complex 96
D08.811.600.741 Pyruvate Dehydrogenase Complex 12
D08.811.600.741.525 Dihydrolipoamide Dehydrogenase 17
D08.811.600.741.625 Dihydrolipoyllysine-Residue Acetyltransferase 1
D08.811.600.741.725 Pyruvate Dehydrogenase (Lipoamide) 1
D08.811.600.795 Sin3 Histone Deacetylase and Corepressor Complex
D08.811.600.850 Sucrase-Isomaltase Complex 1
D08.811.600.896 Tryptophan Synthase 2
D08.811.600.948 Viral Replicase Complex Proteins

PDHX protein, human Chemical MeSH Browser

PDX1 protein, S cerevisiae Chemical MeSH Browser

pyruvate dehydrogenase activator Chemical MeSH Browser

pyruvate dehydrogenase complex component X, Bos taurus Chemical MeSH Browser

pyruvate dehydrogenase multienzyme complex E1 Chemical MeSH Browser

Back Add

Narrower terms