A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.

DUI

D013713 MeSH Browser

CUI

M0021161

CAS

Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-

Previous indexing

Glucosides (1975); Glycosides (1973-1974); Podophyllotoxin (1973-1974)

History note

91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80

Online note

use TENIPOSIDE to search VM 26 1976-80

Public note

91; was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80