Tetrahydrofolate Dehydrogenase [dihydrofolátreduktasa]
topical
16
- Terms
-
dihydrofolátreduktáza
tetrahydrofolátdehydrogenasa
tetrahydrofolátdehydrogenáza
-
Dihydrofolate Dehydrogenase
Dihydrofolate Reductase
Folic Acid Reductase
Persistent link
https://www.medvik.cz/link/D013762
Definition
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
- DUI
- D013762 MeSH Browser
- CUI
- M0021232
- CAS
- 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
- History note
- 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
- Online note
- use TETRAHYDROFOLATE DEHYDROGENASE to search DIHYDROFOLATE DEHYDROGENASE 1966-88
- Public note
- 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Combination
- antagonists & inhibitors
- Folic Acid Antagonists
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AN
- analysis 1
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 4
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 1
- EC
- economics 0
- GE
- genetics 5
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 2
- ME
- metabolism 9
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D08.811.682.662.217
Methylenetetrahydrofolate Dehydrogenase (NAD+)
D08.811.682.662.436
mu-Crystallins
D08.811.682.662.611
Polyamine Oxidase
D08.811.682.662.680
Pyridoxaminephosphate Oxidase
D08.811.682.662.695
Pyrroline Carboxylate Reductases
D08.811.682.662.750
Saccharopine Dehydrogenases