Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.

Annotation

general or unspecified; prefer specific groups or specific drugs; coordinate with specific neurotransmitters /physiol

DUI

D014179 MeSH Browser

CUI

M0021830

Previous indexing

Cytoplasmic Granules (1966-1977); Kinetics (1966-1984); Nerve Endings (1966-1973); Synapses (1966-1971); Synaptic Vesicles (1972-1973); Synaptosomes (1974-1984)

History note

93; WAS TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92

Online note

use NEUROTRANSMITTER UPTAKE INHIBITORS to search TRANSMITTER UPTAKE INHIBITORS, NEURONAL; INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER 1985-92

Public note

93; was TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92