Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.

Annotation

antihypertensives

DUI

D014704 MeSH Browser

CUI

M0022614

Previous indexing

Veratrum (1966-1974)

History note

75

Public note

75; PROTOVERATRINE A was see under CEVANES 1975-79; PROTOVERATRINE A DERIVATIVES was see under CEVANES 1969-77; PROTOVERATRINE was see under VERATRUM 1963-68; CRYPTENAMINE (now see PROTOVERATRINES) was see under VERATRUM ALKALOIDS 1975-79, was see under VERATRUM 1963-74