Down-Regulation [down regulace]

topical
297
Terms

negativní regulace
receptorová negativní regulace

 

Down-Regulation (Physiology)
Downregulation
Receptor Down-Regulation

Persistent link   https://www.medvik.cz/link/D015536
Definition

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

DUI
D015536 MeSH Browser
CUI
M0023902
History note
2002 (1990)
Public note
2002; see Down-Regulation (Physiology) 1990-2001

Allowable subheadings

DE
drug effects 63
GE
genetics 33
IM
immunology 7
PH
physiology 16
RE
radiation effects 4

G Phenomena and Processes
G02 Chemical Phenomena 307
G02.111 Biochemical Phenomena 370
G02.111.007 Acid-Base Equilibrium 443
G02.111.012 Acylation 24
G02.111.017 Aerobiosis 73
G02.111.026 Agglutination 53
G02.111.035 Alkylation 65
G02.111.044 Allosteric Regulation 69
G02.111.053 Amination 7
G02.111.062 Anaerobiosis 143
G02.111.071 Autotrophic Processes 13
G02.111.080 Base Composition 125
G02.111.084 Binding, Competitive 61
G02.111.086 Biocatalysis 82
G02.111.087 Biochemical Processes obsolete
G02.111.092 Biomineralization 4
G02.111.098 Biosynthetic Pathways 49
G02.111.109 Biotinylation 20
G02.111.130 Body Composition 528
G02.111.150 Brain Chemistry 423
G02.111.158 Carbohydrate Metabolism 491
G02.111.165 Citric Acid Cycle 57
G02.111.180 Cyclization 55
G02.111.188 Dealkylation 4
G02.111.192 Deamination 10
G02.111.195 Decarboxylation 17
G02.111.210 DNA Cleavage 15
G02.111.218 DNA Methylation 434
G02.111.222 DNA Repair 464
G02.111.225 DNA Replication 287
G02.111.240 Down-Regulation 297
G02.111.248 Electron Transport 159
G02.111.255 Energy Transfer 322
G02.111.263 Enzyme Activation 379
G02.111.270 Esterification 62
G02.111.323 Halogenation 43
G02.111.375 Heterotrophic Processes 20
G02.111.380 Hydrogenation 24
G02.111.385 Hydroxylation 65
G02.111.490 Kinetics 1 098
G02.111.515 Lipid Peroxidation 757
G02.111.528 Lipogenesis 57
G02.111.534 Lipolysis 181
G02.111.540 Lipoylation 11
G02.111.545 Melanogenesis
G02.111.550 Membrane Fluidity 83
G02.111.560 Molecular Mimicry 37
G02.111.570 Molecular Structure 1 313
G02.111.587 Nitrogen Cycle 6
G02.111.595 Nitrosation 12
G02.111.603 Nucleic Acid Denaturation 62
G02.111.611 Nucleic Acid Hybridization 171
G02.111.619 Nucleic Acid Renaturation 2
G02.111.635 Osmoregulation 10
G02.111.655 Osmosis 77
G02.111.660 Peptide Biosynthesis 43
G02.111.665 Phosphorylation 716
G02.111.669 Phototrophic Processes 25
G02.111.672 Prenylation 14
G02.111.675 Protein Aggregation, Pathological 14
G02.111.679 Protein Binding 1 242
G02.111.688 Protein Folding 106
G02.111.691 Protein Modification, Translational 6
G02.111.694 Protein Multimerization 122
G02.111.700 Protein Stability 94
G02.111.720 Proteolysis 128
G02.111.730 Proteostasis 5
G02.111.740 RNA Cleavage 6
G02.111.750 RNA Folding 4
G02.111.760 RNA Processing, Post-Transcriptional 53
G02.111.770 RNA Replication
G02.111.780 RNA Stability 45
G02.111.810 Sequence Homology 74
G02.111.820 Signal Transduction 2 160
G02.111.830 Structure-Activity Relationship 1 806
G02.111.833 Substrate Cycling 1
G02.111.835 Substrate Specificity 334
G02.111.873 Transcription, Genetic 658
G02.111.905 Up-Regulation 374
G05 Genetic Phenomena 133
G05.308 Gene Expression Regulation 1 073
G05.308.048 Catabolite Repression 2
G05.308.095 Chromatin Assembly and Disassembly 52
G05.308.200 Down-Regulation 297
G05.308.202 Ectopic Gene Expression 2
G05.308.203 Epigenesis, Genetic 374
G05.308.207 Epistasis, Genetic 22
G05.308.215 Frameshifting, Ribosomal 3
G05.308.250 Gene Amplification 333
G05.308.290 Gene Expression Regulation, Archaeal 2
G05.308.300 Gene Expression Regulation, Bacterial 195
G05.308.310 Gene Expression Regulation, Developmental 299
G05.308.320 Gene Expression Regulation, Enzymologic 197
G05.308.330 Gene Expression Regulation, Fungal 119
G05.308.370 Gene Expression Regulation, Neoplastic 789
G05.308.375 Gene Expression Regulation, Plant 298
G05.308.385 Gene Expression Regulation, Viral 37
G05.308.670 Protein Modification, Translational 6
G05.308.700 RNA Processing, Post-Transcriptional 53
G05.308.800 Transcriptional Activation 123
G05.308.850 Up-Regulation 374
G07 Physiological Phenomena 175
G07.690 Pharmacological and Toxicological Phenomena 59
G07.690.773 Pharmacological Phenomena 45
G07.690.773.500 Cytoprotection 54
G07.690.773.750 Depression, Chemical 36
G07.690.773.875 Dose-Response Relationship, Drug 2 361
G07.690.773.937 Down-Regulation 297
G07.690.773.968 Drug Interactions 2 792
G07.690.773.984 Drug Resistance 1 271
G07.690.773.992 Drug Tolerance 268
G07.690.773.996 Stimulation, Chemical 138
G07.690.773.997 Structure-Activity Relationship 1 806
G07.690.773.998 Up-Regulation 374

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