A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

DUI

D015735 MeSH Browser

CUI

M0024116

CAS

Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-

Previous indexing

Abortifacient Agents, Steroidal (1975-1989); Contraceptives, Oral, Synthetic (1975-1989); Estrenes (1975-1989); Glucocorticoids/antagonists & inhibitors (1967-1989)

History note

90

Public note

90