A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.

DUI

D016559 MeSH Browser

CUI

M0025261

CAS

15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-

Previous indexing

Antibiotics, Macrolide (1987-1991); Immunosuppressive Agents (1987-1991)

History note

96; was FK-506 1992-95, was FK 506 (NM) 1987-91

Online note

use TACROLIMUS (NM) to search FK-506 1987-91

Public note

96; was FK-506 1992-95; FK-506 was indexed under ANTIBIOTICS, MACROLIDE 1989-91 & PYRIDINES 1987-89