A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

DUI

D016597 MeSH Prohlížeč

CUI

M0025316

CAS

2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-

Předchozí užití

Antineoplastic Agents (1966-1991); Folic Acid Antagonists (1966-1991); Quinazolines (1966-1991)

Historická pozn.

92; was TRIMETREXATE (NM) 1979-91

Online pozn.

use TRIMETREXATE (NM) to search TRIMETREXATE 1980-91

Veřejná pozn.

92; TRIMETREXATE was indexed under QUINAZOLINES 1979-91