A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

DUI

D016597 MeSH Browser

CUI

M0025316

CAS

2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-

Previous indexing

Antineoplastic Agents (1966-1991); Folic Acid Antagonists (1966-1991); Quinazolines (1966-1991)

History note

92; was TRIMETREXATE (NM) 1979-91

Online note

use TRIMETREXATE (NM) to search TRIMETREXATE 1980-91

Public note

92; TRIMETREXATE was indexed under QUINAZOLINES 1979-91