The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

DUI

D016632 MeSH Browser

CUI

M0025348

Previous indexing

Apolipoproteins (1977-1984); Apolipoproteins A (1985-1991)

History note

1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006

Public note

1992; APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A 1985-1991, under APOLIPOPROTEINS 1979-1984 & under APOPROTEINS 1974-1978; PRO-APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; APOLIPOPROTEIN A-I ISOPROTEINS was indexed under APOLIPOPROTEINS A 1980-2006