Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

DUI

D016875 MeSH Browser

CUI

M0025678

Previous indexing

Microtubule-Associated Proteins (1986-1991); Microtubules (1976-1985)

History note

1992; use TAU (NM) 1977-91

Online note

use TAU PROTEINS (NM) to search TAU (NM) 1980-90

Public note

1992; TAU (NM) was indexed under MICROTUBULE-ASSOCIATED PROTEINS 1985-91 & under PROTEINS 1977-84