Antibodies, Bispecific [protilátky bispecifické]

topical
93
Terms

bispecifické monoklonální protilátky
bispecifické protilátky
bivalentní monoklonální protilátky

 

Bifunctional Antibodies
Bispecific Antibodies
Bispecific Monoclonal Antibodies

Persistent link   https://www.medvik.cz/link/D018033
Definition

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

Annotation
do not coordinate with ANTIBODY FORMATION for /biosynthesis
nekombinuj s deskriptorem TVORBA PROTILÁTEK, místo toho užij podheslo /biosyntéza
DUI
D018033 MeSH Browser
CUI
M0027219
Previous indexing
Antibodies (1985-1993); specific Antibodies (1985-1993)
History note
94
Public note
94

Allowable subheadings

AD
administration & dosage 16
AE
adverse effects 14
AN
analysis
BI
biosynthesis 1
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification 2
DE
drug effects 1
EC
economics
GE
genetics 1
HI
history
IM
immunology 6
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics 5
PD
pharmacology 32
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use 77
TO
toxicity 2
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.124 Blood Proteins 909
D12.776.124.486 Immunoproteins 14
D12.776.124.486.485 Immunoglobulins 1 489
D12.776.124.486.485.114 Antibodies 1 815
D12.776.124.486.485.114.071 Antibodies, Anti-Idiotypic 61
D12.776.124.486.485.114.089 Antibodies, Archaeal
D12.776.124.486.485.114.107 Antibodies, Bacterial 383
D12.776.124.486.485.114.125 Antibodies, Bispecific 93
D12.776.124.486.485.114.143 Antibodies, Blocking 13
D12.776.124.486.485.114.167 Antibodies, Catalytic 4
D12.776.124.486.485.114.179 Antibodies, Fungal 28
D12.776.124.486.485.114.185 Antibodies, Helminth 40
D12.776.124.486.485.114.191 Antibodies, Heterophile 20
D12.776.124.486.485.114.207 Antibodies, Immobilized 13
D12.776.124.486.485.114.224 Antibodies, Monoclonal 4 629
D12.776.124.486.485.114.240 Antibodies, Neoplasm 70
D12.776.124.486.485.114.244 Antibodies, Neutralizing 107
D12.776.124.486.485.114.248 Antibodies, Phospho-Specific 4
D12.776.124.486.485.114.252 Antibodies, Protozoan 110
D12.776.124.486.485.114.254 Antibodies, Viral 1 080
D12.776.124.486.485.114.257 Antigen-Antibody Complex 321
D12.776.124.486.485.114.323 Autoantibodies 1 321
D12.776.124.486.485.114.573 Immune Sera 575
D12.776.124.486.485.114.606 Immunoglobulin Allotypes 1
D12.776.124.486.485.114.619 Immunoglobulin Isotypes 35
D12.776.124.486.485.114.632 Immunoglobulins, Intravenous 365
D12.776.124.486.485.114.656 Insulin Antibodies 25
D12.776.124.486.485.114.664 Isoantibodies 56
D12.776.124.486.485.114.715 Oligoclonal Bands 42
D12.776.124.486.485.114.820 Plantibodies 2
D12.776.124.486.485.114.837 Precipitins 18
D12.776.124.486.485.114.890 Reagins 5
D12.776.124.790 Serum Globulins 61
D12.776.124.790.651 Immunoglobulins 1 489
D12.776.124.790.651.114 Antibodies 1 815
D12.776.124.790.651.114.071 Antibodies, Anti-Idiotypic 61
D12.776.124.790.651.114.107 Antibodies, Archaeal
D12.776.124.790.651.114.125 Antibodies, Bacterial 383
D12.776.124.790.651.114.134 Antibodies, Bispecific 93
D12.776.124.790.651.114.143 Antibodies, Blocking 13
D12.776.124.790.651.114.167 Antibodies, Catalytic 4
D12.776.124.790.651.114.179 Antibodies, Fungal 28
D12.776.124.790.651.114.185 Antibodies, Helminth 40
D12.776.124.790.651.114.191 Antibodies, Heterophile 20
D12.776.124.790.651.114.207 Antibodies, Immobilized 13
D12.776.124.790.651.114.224 Antibodies, Monoclonal 4 629
D12.776.124.790.651.114.240 Antibodies, Neoplasm 70
D12.776.124.790.651.114.244 Antibodies, Neutralizing 107
D12.776.124.790.651.114.248 Antibodies, Phospho-Specific 4
D12.776.124.790.651.114.252 Antibodies, Protozoan 110
D12.776.124.790.651.114.254 Antibodies, Viral 1 080
D12.776.124.790.651.114.257 Antigen-Antibody Complex 321
D12.776.124.790.651.114.323 Autoantibodies 1 321
D12.776.124.790.651.114.573 Immune Sera 575
D12.776.124.790.651.114.580 Immunoconjugates 210
D12.776.124.790.651.114.606 Immunoglobulin Allotypes 1
D12.776.124.790.651.114.619 Immunoglobulin Isotypes 35
D12.776.124.790.651.114.632 Immunoglobulins, Intravenous 365
D12.776.124.790.651.114.656 Insulin Antibodies 25
D12.776.124.790.651.114.664 Isoantibodies 56
D12.776.124.790.651.114.715 Oligoclonal Bands 42
D12.776.124.790.651.114.820 Plantibodies 2
D12.776.124.790.651.114.837 Precipitins 18
D12.776.124.790.651.114.890 Reagins 5
D12.776.377 Globulins 68
D12.776.377.715 Serum Globulins 61
D12.776.377.715.548 Immunoglobulins 1 489
D12.776.377.715.548.114 Antibodies 1 815
D12.776.377.715.548.114.071 Antibodies, Anti-Idiotypic 61
D12.776.377.715.548.114.107 Antibodies, Archaeal
D12.776.377.715.548.114.125 Antibodies, Bacterial 383
D12.776.377.715.548.114.134 Antibodies, Bispecific 93
D12.776.377.715.548.114.143 Antibodies, Blocking 13
D12.776.377.715.548.114.167 Antibodies, Catalytic 4
D12.776.377.715.548.114.179 Antibodies, Fungal 28
D12.776.377.715.548.114.185 Antibodies, Helminth 40
D12.776.377.715.548.114.191 Antibodies, Heterophile 20
D12.776.377.715.548.114.207 Antibodies, Immobilized 13
D12.776.377.715.548.114.224 Antibodies, Monoclonal 4 629
D12.776.377.715.548.114.240 Antibodies, Neoplasm 70
D12.776.377.715.548.114.244 Antibodies, Neutralizing 107
D12.776.377.715.548.114.248 Antibodies, Phospho-Specific 4
D12.776.377.715.548.114.252 Antibodies, Protozoan 110
D12.776.377.715.548.114.254 Antibodies, Viral 1 080
D12.776.377.715.548.114.257 Antigen-Antibody Complex 321
D12.776.377.715.548.114.323 Autoantibodies 1 321
D12.776.377.715.548.114.573 Immune Sera 575
D12.776.377.715.548.114.580 Immunoconjugates 210
D12.776.377.715.548.114.606 Immunoglobulin Allotypes 1
D12.776.377.715.548.114.619 Immunoglobulin Isotypes 35
D12.776.377.715.548.114.632 Immunoglobulins, Intravenous 365
D12.776.377.715.548.114.656 Insulin Antibodies 25
D12.776.377.715.548.114.664 Isoantibodies 56
D12.776.377.715.548.114.715 Oligoclonal Bands 42
D12.776.377.715.548.114.820 Plantibodies 2
D12.776.377.715.548.114.837 Precipitins 18
D12.776.377.715.548.114.890 Reagins 5

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