Superantigens [superantigeny]
- Terms
-
Superantigen
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
- Annotation
- coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
- DUI
- D018089 MeSH Browser
- CUI
- M0027285
- Previous indexing
- specific antigens (1989-1993)
- History note
- 94
- Public note
- 94
Allowable subheadings
- AD
- administration & dosage 1
- AE
- adverse effects 2
- AN
- analysis 2
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CH
- chemistry 1
- CL
- classification 1
- DE
- drug effects
- EC
- economics
- GE
- genetics 6
- HI
- history
- IM
- immunology 4
- IP
- isolation & purification 4
- ME
- metabolism 1
- PD
- pharmacology
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- TU
- therapeutic use
- TO
- toxicity 1
- UL
- ultrastructure
- UR
- urine
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