Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

DUI

D018774 MeSH Browser

CUI

M0028105

Previous indexing

Retroviridae Proteins (1987-1989); Retroviridae Proteins, Oncogenic (1990-1994)

History note

95; was ONCOGENE PROTEIN ERBA (NM) 1987-94

Online note

use ONCOGENE PROTEINS V-ERBA (NM) to search ONCOGENE PROTEIN ERBA 1987-94

Public note

95; ONCOGENE PROTEIN ERBA was indexed under RETROVIRIDAE PROTEINS, ONCOGENIC 1990-94 & RETROVIRIDAE PROTEINS 1987-89