Antineoplastic Agents, Alkylating [antitumorózní látky alkylující]
- Terms
-
alkylační cytostatika
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Alkylating Agents, Antineoplastic
Alkylating Antineoplastic Agents
Alkylating Antineoplastic Drugs
Alkylating Antineoplastics
Alkylating Drugs, Antineoplastic
Antineoplastic Alkylating Agents
Antineoplastic Drugs, Alkylating
Antineoplastics, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
- DUI
- D018906 MeSH Browser
- CUI
- M0028268
- Previous indexing
- Alkylating Agents (1966-1995); Antineoplastic Agents (1966-1995)
- History note
- 96
- Public note
- 96
Allowable subheadings
- AD
- administration & dosage 31
- AE
- adverse effects 36
- AN
- analysis 3
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 4
- CL
- classification 1
- EC
- economics 0
- HI
- history 1
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 2
- PK
- pharmacokinetics 8
- PD
- pharmacology 17
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 1
- SD
- supply & distribution 0
- TU
- therapeutic use 65
- TO
- toxicity 8
- UR
- urine 0