The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the turn. The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)

Annotation

do not confuse with HELIX-LOOP-HELIX MOTIFS

DUI

D019077 MeSH Browser

CUI

M0028477

Previous indexing

Amino Acid Sequence (1985-1994); Helix-Loop-Helix Motifs (1994-1995)

History note

96; was see HELIX-LOOP-HELIX MOTIFS 1994-95

Online note

use HELIX-LOOP-HELIX MOTIFS to search HELIX-TURN-HELIX MOTIFS 1994-95

Public note

96; was see HELIX-LOOP-HELIX MOTIFS 1994-95