A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

DUI

D019716 MeSH Prohlížeč

CUI

M0029272

Předchozí užití

Neoplasm Proteins (1989-1993); Proteins (1990-1997)

Historická pozn.

1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997

Veřejná pozn.

1998; TISSUE INHIBITOR OF METALLOPROTEINASE 2 was indexed under PROTEINS 1990-97 & NEOPLASM PROTEINS 1989-1993