Metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) degrade type IV collagen, and represent important tissue remodeling enzymes in several kidney disorders. In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n = 18, median age 5) and focal segmental glomerulosclerosis (FSGS, n = 16, median age 15). We found that urinary concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were significantly elevated in FSGS patients as compared to SSNS in both relapse and remission (p < 0.002). Furthermore, urinary levels of these enzymes are increased early on in the FSGS disease process (chronic kidney disease stages 1 and 2). The findings from this pilot study suggest that MMPs and TIMPs have the potential to represent candidate, early non-invasive biomarkers for diagnosis and/or response to therapy. In addition, they may represent therapeutic targets for preventing chronic kidney disease progression in FSGS.
- MeSH
- biologické markery moč MeSH
- dítě MeSH
- ELISA MeSH
- fokálně segmentální glomeruloskleróza enzymologie moč MeSH
- lidé MeSH
- matrixová metaloproteinasa 2 moč MeSH
- matrixová metaloproteinasa 9 moč MeSH
- mladiství MeSH
- nefrotický syndrom moč MeSH
- pilotní projekty MeSH
- předškolní dítě MeSH
- tkáňový inhibitor metaloproteinasy 1 moč MeSH
- tkáňový inhibitor metaloproteinasy 2 moč MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
