eIF-2 Kinase [kinasa eIF-2]

topical
8
Terms

kinasa p68
kináza eIF-2
proteinkinasa aktivovaná RNA
proteinkinasa PKR

 

DAI Protein Kinase
Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
Double Stranded RNA-Dependent Kinase (dsl)
dsRNA-Activated Inhibitor
DSRNA-Dep Protein Kinase
eIF-2alpha Kinase
eRF, eIF-2 Recycling Factor
Eukaryotic Initiation Factor 2alpha Kinase
Heme Controlled Repressor
Heme-Controlled Inhibitor
Heme-Controlled Translational Repressor
Heme-Regulated eIF-2alpha Kinase
Hemin Controlled Repressor
Hemin-Controlled Translational Repressor
p65 Kinase
p68 Kinase
P68 Protein Kinase
Protein Kinase PKR
Protein Kinase, RNA Activated
RNA-Dependent Protein Kinase
Self-Phosphorylating Protein Kinase
TIK Kinase

Persistent link   https://www.medvik.cz/link/D019892
Definition

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

DUI
D019892 MeSH Browser
CUI
M0029534
Previous indexing
Protein Kinases (1980-1993); Protein-Serine-Threonine Kinases (1993-1997)
History note
98; use EIF-2 KINASE (NM) 1980-97
Public note
98; EIF-2 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTEIN KINASES 1980-93

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors 1
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency 1
DE
drug effects
EC
economics
GE
genetics 6
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 6
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 271
D08.811.913.696.620.682.700.062 Activin Receptors 5
D08.811.913.696.620.682.700.074 AMP-Activated Protein Kinase Kinases 1
D08.811.913.696.620.682.700.085 AMP-Activated Protein Kinases 41
D08.811.913.696.620.682.700.097 Ataxia Telangiectasia Mutated Proteins 89
D08.811.913.696.620.682.700.103 Aurora Kinases 4
D08.811.913.696.620.682.700.108 Autophagy-Related Protein-1 Homolog
D08.811.913.696.620.682.700.109 Bone Morphogenetic Protein Receptors 3
D08.811.913.696.620.682.700.125 Calcium-Calmodulin-Dependent Protein Kinases 10
D08.811.913.696.620.682.700.140 Casein Kinases 1
D08.811.913.696.620.682.700.143 Checkpoint Kinase 1 19
D08.811.913.696.620.682.700.145 Checkpoint Kinase 2 49
D08.811.913.696.620.682.700.150 Cyclic Nucleotide-Regulated Protein Kinases
D08.811.913.696.620.682.700.250 DNA-Activated Protein Kinase 14
D08.811.913.696.620.682.700.275 Doublecortin-Like Kinases
D08.811.913.696.620.682.700.288 Dyrk Kinases
D08.811.913.696.620.682.700.300 eIF-2 Kinase 8
D08.811.913.696.620.682.700.364 G-Protein-Coupled Receptor Kinases 2
D08.811.913.696.620.682.700.397 Germinal Center Kinases 2
D08.811.913.696.620.682.700.429 Glycogen Synthase Kinases
D08.811.913.696.620.682.700.494 I-kappa B Kinase 9
D08.811.913.696.620.682.700.526 Interleukin-1 Receptor-Associated Kinases 3
D08.811.913.696.620.682.700.534 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 2
D08.811.913.696.620.682.700.542 Lim Kinases 2
D08.811.913.696.620.682.700.559 MAP Kinase Kinase Kinases 48
D08.811.913.696.620.682.700.565 Mitogen-Activated Protein Kinase Kinases 41
D08.811.913.696.620.682.700.567 Mitogen-Activated Protein Kinases 100
D08.811.913.696.620.682.700.576 Myotonin-Protein Kinase 2
D08.811.913.696.620.682.700.579 NF-kappaB-Inducing Kinase 1
D08.811.913.696.620.682.700.581 NIMA-Related Kinases 4
D08.811.913.696.620.682.700.586 Oncogene Protein v-akt 5
D08.811.913.696.620.682.700.596 p21-Activated Kinases 9
D08.811.913.696.620.682.700.606 Phytochrome A 2
D08.811.913.696.620.682.700.616 Polo-like Kinases
D08.811.913.696.620.682.700.626 Positive Transcriptional Elongation Factor B 4
D08.811.913.696.620.682.700.646 Proline-Directed Protein Kinases 1
D08.811.913.696.620.682.700.725 Protein Kinase C 138
D08.811.913.696.620.682.700.745 3-Phosphoinositide-Dependent Protein Kinases
D08.811.913.696.620.682.700.750 Protein Kinase D2
D08.811.913.696.620.682.700.755 Proto-Oncogene Proteins c-akt 117
D08.811.913.696.620.682.700.759 Proto-Oncogene Proteins c-bcr 19
D08.811.913.696.620.682.700.776 Proto-Oncogene Proteins c-pim-1 1
D08.811.913.696.620.682.700.783 Pyruvate Dehydrogenase Acetyl-Transferring Kinase
D08.811.913.696.620.682.700.789 Receptor, Transforming Growth Factor-beta Type I 2
D08.811.913.696.620.682.700.795 Receptor, Transforming Growth Factor-beta Type II
D08.811.913.696.620.682.700.801 Receptor-Interacting Protein Serine-Threonine Kinases 7
D08.811.913.696.620.682.700.814 rho-Associated Kinases 26
D08.811.913.696.620.682.700.862 Ribosomal Protein S6 Kinases 1
D08.811.913.696.620.682.700.897 Serine-Threonine Kinase 3
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 193
D08.811.913.696.620.682.700.965 Vacuolar Sorting Protein VPS15
D08.811.913.696.620.682.700.982 WNK Lysine-Deficient Protein Kinase 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.563 Protein Serine-Threonine Kinases 271
D12.776.476.563.062 Activin Receptors 5
D12.776.476.563.074 AMP-Activated Protein Kinase Kinases 1
D12.776.476.563.085 AMP-Activated Protein Kinases 41
D12.776.476.563.097 Ataxia Telangiectasia Mutated Proteins 89
D12.776.476.563.103 Aurora Kinases 4
D12.776.476.563.108 Autophagy-Related Protein-1 Homolog
D12.776.476.563.109 Bone Morphogenetic Protein Receptors 3
D12.776.476.563.125 Calcium-Calmodulin-Dependent Protein Kinases 10
D12.776.476.563.140 Casein Kinases 1
D12.776.476.563.143 Checkpoint Kinase 1 19
D12.776.476.563.145 Checkpoint Kinase 2 49
D12.776.476.563.150 Cyclic Nucleotide-Regulated Protein Kinases
D12.776.476.563.250 DNA-Activated Protein Kinase 14
D12.776.476.563.275 Doublecortin-Like Kinases
D12.776.476.563.288 Dyrk Kinases
D12.776.476.563.300 eIF-2 Kinase 8
D12.776.476.563.364 G-Protein-Coupled Receptor Kinases 2
D12.776.476.563.397 Germinal Center Kinases 2
D12.776.476.563.429 Glycogen Synthase Kinases
D12.776.476.563.494 I-kappa B Kinase 9
D12.776.476.563.526 Interleukin-1 Receptor-Associated Kinases 3
D12.776.476.563.534 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 2
D12.776.476.563.542 Lim Kinases 2
D12.776.476.563.554 MAP Kinase Kinase Kinases 48
D12.776.476.563.565 Mitogen-Activated Protein Kinase Kinases 41
D12.776.476.563.567 Mitogen-Activated Protein Kinases 100
D12.776.476.563.576 Myotonin-Protein Kinase 2
D12.776.476.563.579 NF-kappaB-Inducing Kinase 1
D12.776.476.563.581 NIMA-Related Kinases 4
D12.776.476.563.586 Oncogene Protein v-akt 5
D12.776.476.563.596 p21-Activated Kinases 9
D12.776.476.563.606 Phytochrome A 2
D12.776.476.563.616 Polo-like Kinases
D12.776.476.563.626 Positive Transcriptional Elongation Factor B 4
D12.776.476.563.646 Proline-Directed Protein Kinases 1
D12.776.476.563.725 Protein Kinase C 138
D12.776.476.563.745 3-Phosphoinositide-Dependent Protein Kinases
D12.776.476.563.750 Protein Kinase D2
D12.776.476.563.755 Proto-Oncogene Proteins c-akt 117
D12.776.476.563.759 Proto-Oncogene Proteins c-bcr 19
D12.776.476.563.776 Proto-Oncogene Proteins c-pim-1 1
D12.776.476.563.783 Pyruvate Dehydrogenase Acetyl-Transferring Kinase
D12.776.476.563.789 Receptor, Transforming Growth Factor-beta Type I 2
D12.776.476.563.795 Receptor, Transforming Growth Factor-beta Type II
D12.776.476.563.801 Receptor-Interacting Protein Serine-Threonine Kinases 7
D12.776.476.563.814 rho-Associated Kinases 26
D12.776.476.563.862 Ribosomal Protein S6 Kinases 1
D12.776.476.563.897 Serine-Threonine Kinase 3
D12.776.476.563.931 TOR Serine-Threonine Kinases 193
D12.776.476.563.965 Vacuolar Sorting Protein VPS15
D12.776.476.563.982 WNK Lysine-Deficient Protein Kinase 1

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