Immunophilins [imunofiliny]

topical
4
Terms

imunofilin
neurofilin
neurofiliny

 

Immunophilin
Neurophilin
Neurophilins

Persistent link   https://www.medvik.cz/link/D020104
Definition

Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.

Annotation
don't confuse entry term NEUROPHILINS with NEUROPILINS
DUI
D020104 MeSH Browser
CUI
M0029838
Previous indexing
Immunosuppressive Agents (1990-1998)
History note
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
Public note
2004; NEUROPHILIN was indexed under LYMPHOKINES 1974-2003; ENDOTHELIAL GROWTH FACTORS 1991-2003 & INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2002

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 2
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 2
PK
pharmacokinetics
PD
pharmacology 1
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.399 Isomerases 18
D08.811.399.325 cis-trans-Isomerases 4
D08.811.399.325.500 Peptidylprolyl Isomerase 9
D08.811.399.325.500.400 Immunophilins 4
D08.811.399.325.500.400.300 Cyclophilins 6
D08.811.399.325.500.400.700 Tacrolimus Binding Proteins 17
D08.811.399.325.500.700 NIMA-Interacting Peptidylprolyl Isomerase 1
D08.811.399.325.500.850 Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.543 Membrane Proteins 850
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.750.705 Receptors, Immunologic 129
D12.776.543.750.705.012 Lymphocyte Activation Gene 3 Protein 1
D12.776.543.750.705.023 Leukocyte Immunoglobulin-like Receptor B1 1
D12.776.543.750.705.045 Lipopolysaccharide Receptors 65
D12.776.543.750.705.222 Costimulatory and Inhibitory T-Cell Receptors 2
D12.776.543.750.705.400 Immunophilins 4
D12.776.543.750.705.400.350 Cyclophilins 6
D12.776.543.750.705.400.700 Tacrolimus Binding Proteins 17
D12.776.543.750.705.408 Integrins 118
D12.776.543.750.705.675 Platelet Membrane Glycoproteins 33
D12.776.543.750.705.816 Receptors, Antigen 20
D12.776.543.750.705.833 Receptors, Complement 4
D12.776.543.750.705.852 Receptors, Cytokine 81
D12.776.543.750.705.871 Receptors, Fc 54
D12.776.543.750.705.873 Receptors, Formyl Peptide 3
D12.776.543.750.705.876 Receptors, Laminin 1
D12.776.543.750.705.877 Receptors, Lymphocyte Homing 2
D12.776.543.750.705.880 Receptors, Mitogen 7
D12.776.543.750.705.895 Receptors, Natural Killer Cell 9
D12.776.543.750.705.910 Receptors, Pattern Recognition 26
D12.776.543.750.705.940 Receptors, Scavenger 7
D12.776.543.750.705.970 Signaling Lymphocytic Activation Molecule Family 3
D12.776.543.750.705.985 Triggering Receptor Expressed on Myeloid Cells-1 4
D12.776.827 Receptors, Drug 173
D12.776.827.137 Imidazoline Receptors 19
D12.776.827.344 Immunophilins 4
D12.776.827.344.300 Cyclophilins 6
D12.776.827.344.700 Tacrolimus Binding Proteins 17
D12.776.827.550 Receptors, Phencyclidine 1
D12.776.827.775 Sulfonylurea Receptors 6

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