Genes, BRCA2 [geny BRCA2]

topical
248
Terms

BRCA2 gen
BRCA2 geny
gen BRCA2

 

BRCA2 Gene

Persistent link   https://www.medvik.cz/link/D024522
Definition

A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

Annotation
BRCA stands for "BReast CAncer"
DUI
D024522 MeSH Browser
CUI
M0370672
Previous indexing
Genes, Tumor Suppressor (1995-2001)
History note
2002
Public note
2002

Allowable subheadings

DE
drug effects 23
ES
ethics
PH
physiology 10
RE
radiation effects 1

G Phenomena and Processes
G05 Genetic Phenomena 135
G05.360 Genetic Structures 25
G05.360.340 Genome 363
G05.360.340.024 Genome Components 13
G05.360.340.024.340 Genes 673
G05.360.340.024.340.375 Genes, Neoplasm 34
G05.360.340.024.340.375.249 Genes, Tumor Suppressor 165
G05.360.340.024.340.375.249.050 Genes, APC 40
G05.360.340.024.340.375.249.100 Genes, BRCA1 280
G05.360.340.024.340.375.249.105 Genes, BRCA2 248
G05.360.340.024.340.375.249.200 Genes, DCC 2
G05.360.340.024.340.375.249.320 Genes, MCC
G05.360.340.024.340.375.249.340 Genes, Neurofibromatosis 1 14
G05.360.340.024.340.375.249.345 Genes, Neurofibromatosis 2 1
G05.360.340.024.340.375.249.375 Genes, p16 19
G05.360.340.024.340.375.249.385 Genes, p53 264
G05.360.340.024.340.375.249.400 Genes, Retinoblastoma 15
G05.360.340.024.340.375.249.420 Genes, Wilms Tumor 20
G05.360.340.024.340.415 Genes, Recessive 49
G05.360.340.024.340.415.400 Genes, Tumor Suppressor 165
G05.360.340.024.340.415.400.050 Genes, APC 40
G05.360.340.024.340.415.400.100 Genes, BRCA1 280
G05.360.340.024.340.415.400.105 Genes, BRCA2 248
G05.360.340.024.340.415.400.200 Genes, DCC 2
G05.360.340.024.340.415.400.320 Genes, MCC
G05.360.340.024.340.415.400.340 Genes, Neurofibromatosis 1 14
G05.360.340.024.340.415.400.345 Genes, Neurofibromatosis 2 1
G05.360.340.024.340.415.400.375 Genes, p16 19
G05.360.340.024.340.415.400.385 Genes, p53 264
G05.360.340.024.340.415.400.400 Genes, Retinoblastoma 15
G05.360.340.024.340.415.400.420 Genes, Wilms Tumor 20

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