A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

DUI

D040281 MeSH Browser

CUI

M0175703

Previous indexing

Receptors, Growth Factor (1993-2002); Proto-Oncogene Proteins (1991-2002); Receptor Protein-Tyrosine Kinases (1991-2002)

History note

2003; use VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (NM) 1990-2002; for FLK-1 RECEPTOR TYROSINE KINASE use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1993-2002

Public note

2003; PROTO-ONCOGENE PROTEIN FLT (now VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1) was indexed under PROTO-ONCOGENE PROTEINS & RECEPTOR PROTEIN-TYROSINE KINASE 1991-2002