A region of DNA that is highly polymorphic and is prone to strand breaks, rearrangements or other MUTATIONS because of the nature of its sequence. These regions often harbor palindromic, or repetitive sequences (REPETITIVE SEQUENCES, NUCLEIC ACID). Variability in stability of the DNA sequence is seen at CHROMOSOME FRAGILE SITES.

DUI

D043243 MeSH Browser

CUI

M0029212

History note

2004 (1998); use TRINUCLEOTIDE REPEAT EXPANSION 1998-2003

Public note

2004; see TRINUCLEOTIDE REPEAT EXPANSION 1999-2003