A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.

DUI

D044346 MeSH Browser

CUI

M0267233

Previous indexing

Receptors, Serotonin (1996-2003)

History note

2004; use RECEPTOR, SEROTONIN, 5-HT1D (NM) 1996-2003

Public note

2004; SEROTONIN 1D RECEPTOR (now RECEPTOR, SEROTONIN, 5-HT1D) was indexed under RECEPTORS, SEROTONIN 1996-2003; SEROTONIN 1DALPHA RECEPTOR was indexed under RECEPTORS, SEROTONIN 1997-2003;