Metabolic Detoxication, Phase I [I. fáze biotransformace]

topical
7
Terms

I. fáze metabolické detoxikace
metabolická detoxikace oxidační
metabolická detoxikace, I. fáze

 

Metabolic Detoxication, Oxidative
Metabolic Detoxification, Phase I
Phase I Detoxification

Persistent link   https://www.medvik.cz/link/D050216
Definition

Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

DUI
D050216 MeSH Browser
CUI
M0473292
History note
2006
Public note
2006

Allowable subheadings

EH
ethnology 0
GE
genetics 1
IM
immunology 0
PH
physiology 0
RE
radiation effects 0

G Phenomena and Processes
G03 Metabolic Phenomena obsolete
G03.171 Biotransformation 794
G03.171.450 Inactivation, Metabolic 114
G03.171.450.500 Metabolic Detoxication, Phase I 7
G03.171.450.750 Metabolic Detoxication, Phase II 6
G03.787 Pharmacokinetics 750
G03.787.225 Biotransformation 794
G03.787.225.450 Inactivation, Metabolic 114
G03.787.225.450.500 Metabolic Detoxication, Phase I 7
G03.787.225.450.750 Metabolic Detoxication, Phase II 6
G07 Physiological Phenomena 176
G07.690 Pharmacological and Toxicological Phenomena 59
G07.690.725 Pharmacokinetics 750
G07.690.725.225 Biotransformation 794
G07.690.725.225.450 Inactivation, Metabolic 114
G07.690.725.225.450.500 Metabolic Detoxication, Phase I 7
G07.690.725.225.450.750 Metabolic Detoxication, Phase II 6

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