Homogentisate 1,2-Dioxygenase [homogentisát-1,2-dioxygenasa]
topical
1
- Terms
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homogentisát-1,2-dioxygenáza
homogentisátdioxygenasa
homogentisátdioxygenáza
homogentisátoxidáza
homogentisátoxygenasa
homogentisátoxygenáza
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Homogentisate Dioxygenase
Homogentisate Oxidase
Homogentisate Oxygenase
Homogentisic Acid Oxidase
Persistent link
https://www.medvik.cz/link/D050560
Definition
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
- DUI
- D050560 MeSH Browser
- CUI
- M0076145
- Previous indexing
- Dioxygenases (1969-2005)
- History note
- 2006(1969)
- Public note
- 2006; HOMOGENTISATE 1,2-DIOXYGENASE was indexed under DIOXYGENASES 1969-2005, OXYGENASES 1983-2004, & under HOMOGENTISIC ACID 1973-1982
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency 1
- DE
- drug effects
- EC
- economics
- GE
- genetics 1
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs
D08.811.682.690.416.139
AlkB Enzymes
D08.811.682.690.416.328
3-Hydroxyanthranilate 3,4-Dioxygenase
D08.811.682.690.416.652
Protocatechuate-3,4-Dioxygenase