Presenilin-2 [presenilin-2]
- Terms
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presenilin 2
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Presenilin 2
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
- DUI
- D053766 MeSH Browser
- CUI
- M0257716
- Previous indexing
- Alzheimer Disease (1996-2006); Membrane Proteins (1996-2006)
- History note
- 2007
- Public note
- 2007; was indexed under MEMBRANE PROTEINS 1996-2006
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 1
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
PSEN2 protein, human Chemical MeSH Browser
Psen2 protein, mouse Chemical MeSH Browser
Psen2 protein, rat Chemical MeSH Browser
Psen2 protein, zebrafish Chemical MeSH Browser