Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

DUI

D053766 MeSH Prohlížeč

CUI

M0257716

Předchozí užití

Alzheimer Disease (1996-2006); Membrane Proteins (1996-2006)

Historická pozn.

2007

Veřejná pozn.

2007; was indexed under MEMBRANE PROTEINS 1996-2006