Perforin [perforin]
- Terms
-
cytolysin
-
Cytolysin
Lymphocyte Pore-Forming Protein
Perforin 1
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
- DUI
- D054353 MeSH Browser
- CUI
- M0133732
- Previous indexing
- Membrane Glycoproteins (1985-2007); Pore Forming Cytotoxic Proteins (1985-2007)
- History note
- 2008
- Public note
- 2008; PERFORIN was indexed under MEMBRANE GLYCOPROTEINS & PORE FORMING CYTOTOXIC PROTEINS 1985-2007
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- DF
- deficiency
- DE
- drug effects 2
- EC
- economics
- GE
- genetics 4
- HI
- history
- IM
- immunology
- IP
- isolation & purification 2
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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